Kinase Inhibitors Projects

There are more than 500 distinct protein kinases in the cell that form a complex interaction network and by reversible protein phosphorylation regulate intracellular signal transduction. Dysfunction of kinase activity can cause many human diseases and since protein kinases are critical initiators, mediators and amplifiers of multiple signalling pathways associated with malignant transformation and aggressiveness of the disease, they remain a major focus of research initiatives identifying novel targeted therapies.

Selvita started its first kinase discovery program in 2008. Set of research tools developed within the platform enables fast target validation as well as rapid and effective development of kinase inhibitors showing therapeutic potential in oncology.