Versatility of the fragment based drug discovery approach

Fragment screening (FS) become nowadays rather a well-accepted source of hits in the process of drug discovery. It is now a common practice, particularly within large pharmaceutical companies to run FS in parallel with HTS (high-throughput screening). It has a number of potential advantages over screening larger compounds as an…

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Screening quality controls – a key issue for robust assay execution

In this article we delve into the fundamental scientific challenges of in vitro High Throughput Screening (HTS) assay development. Often we hear why the drug discovery process is so complicated: because biology is complex, still poorly understood and often unpredictable. In fact, taking a drug all the way from initial…

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