Our science

Throughout 13 years of Selvita operations, we’ve had the opportunity to execute a variety of exciting and complex projects for our Clients.
The nature of our business is based on high degree of trust and confidentiality, however we are always very excited to co-author or contribute to scientific publications which present our work.

Whenever possible we publish and present materials such as journal publications, posters, case studies or technical notes, aiming to show the scope of experience of our scientific team.
In the section below, you can find the continuously updated information on our recent publications.

Our science

Blog

15 September 2020

Deuteration: a way to put an old drug in the spotlight again

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13 August 2020

Chemistry under high pressure: a curiosity or a practical solution?

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16 July 2020

COVID-19, a new battleground for drug discovery

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18 June 2020

PROTAC drug discovery – prior preparation and planning

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Case studies

16 July 2020

Case Study 02 (from H2L to Clinical Trials)

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13 July 2020

Case Study 01 (Screen-to-Lead)

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More case studies

Presentations

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Poster presentations

Poster icon
26 August 2020 LC/HRMS ORBITRAP Technique - Essential tool in drug development process
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07 July 2020 Cloning and Expression Platform for Production of Recombinant Proteins
The poster describes the cost and time-effective Selvita platform for cloning and E. coli expression (which is only one of our platforms for expression).
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07 July 2020 A short synthesis of Dronedarone
Selvita’s chemists are adept at designing enhanced approaches to target molecules and in this poster and paper illustrate how they collaborated on a synthesis of the atrial fibrillation drug Dronedrone which has been reworked to more than half the number of synthetic steps using efficient and environmentally friendly chemistry.
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Publications

Poster icon
Mitogenic activity and proliferative effect of a New-developed short acting Insulin analogue Human insulin analogues with modified amino acid sequence may exert stronger proliferative effect and carcinogenic potential than insulin itself. The objective of the study was to assess mitogenic activity and activation of proliferation in tumorigenic and non-tumorigenic cell lines upon stimulation with a new-developed short-acting B28Lys-B29Pro human insulin (KP) in comparison to EU Pharmacopeia human insulin standard (HIS) and insulin AspB10 with strong mitogenic, cancerogenic activity. Find out more
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Technical notes

Development of an in vitro assay of neurodegeneration using human pluripotent stem cell–derived neurons

Human induced pluripotent stem cells (hiPSC) are obtained by genetically reprogramming somatic cells from human tissues, after which these cells can be further differentiated virtually into any cell types. hiPSC are derived from normal adults or from diseased patients and carry protein mutations that are able to compromise the cell physiology.

As consequence, hiPSC-derived cells reveal a high potential for studying pathophysiological processes in basically all pathological areas including CNS, PNS, peripheral tissues (cardiac, hepatic, pulmonary, muscular, vessel, blood, etc.)…

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