Our science

Throughout 13 years of Selvita operations, we’ve had the opportunity to execute a variety of exciting and complex projects for our Clients.
The nature of our business is based on high degree of trust and confidentiality, however we are always very excited to co-author or contribute to scientific publications which present our work.

Whenever possible we publish and present materials such as journal publications, posters, case studies or technical notes, aiming to show the scope of experience of our scientific team.
In the section below, you can find the continuously updated information on our recent publications.

Our science

Blog

13 August 2020

Chemistry under high pressure: a curiosity or a practical solution?

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16 July 2020

COVID-19, a new battleground for drug discovery

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18 June 2020

PROTAC drug discovery – prior preparation and planning

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20 January 2020

DATA INTEGRITY IN QUALITY CONTROL LABORATORY – HOW TO ENSURE IT?

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Case studies

16 July 2020

Case Study 02 (from H2L to Clinical Trials)

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13 July 2020

Case Study 01 (Screen-to-Lead)

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More case studies

Presentations

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Poster presentations

Poster icon
07 July 2020 Cloning and Expression Platform for Production of Recombinant Proteins
The poster describes the cost and time-effective Selvita platform for cloning and E. coli expression (which is only one of our platforms for expression).
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07 July 2020 A short synthesis of Dronedarone
Selvita’s chemists are adept at designing enhanced approaches to target molecules and in this poster and paper illustrate how they collaborated on a synthesis of the atrial fibrillation drug Dronedrone which has been reworked to more than half the number of synthetic steps using efficient and environmentally friendly chemistry.
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07 July 2020 A new competitive strategy for the industrial synthesis of drugs based on chiral amines via utilizing the waste isomer by flow chemistry
Selvita has an ongoing commitment to expand chemistry technology to facilitate efficient access to intermediates and final compounds. One such technique which has been developed at Selvita is the application of flow chemistry techniques in synthesis.   In the linked poster Selvita scientists have described a flow chemistry approach to recycle the “waste’ isomer product from a non-enantiospecific primary amine synthesis, offering a means to enhance the yield of desired isomer in synthesis of drugs such as Cinacalcet and Rivastigimine.
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Publications

Poster icon
Mitogenic activity and proliferative effect of a New-developed short acting Insulin analogue Human insulin analogues with modified amino acid sequence may exert stronger proliferative effect and carcinogenic potential than insulin itself. The objective of the study was to assess mitogenic activity and activation of proliferation in tumorigenic and non-tumorigenic cell lines upon stimulation with a new-developed short-acting B28Lys-B29Pro human insulin (KP) in comparison to EU Pharmacopeia human insulin standard (HIS) and insulin AspB10 with strong mitogenic, cancerogenic activity. Find out more
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Technical notes

Recombinant Stable Cell Line Development

The generation of cell lines overexpressing particular proteins on which drug discovery programs are often based, is necessary for assay development in screening campaigns using initial target-based identification of hit compounds. Recombinant stable cell lines are also used for toxicity studies and general in vitro testing.

Methods to be used and the cell background for the generation of a cell line could depend on several factors: i) the complexity of protein (e.g. dimensions, carrying antibiotic resistance, presence of tags etc.)…

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