Kraków, Poland – 08 March 2017 – Selvita and Sandoz researchers have recently jointly published a review on the “Evolution of synthetic routes towards homochiral Tapentadol“, which appeared in the Tetrahedron: Asymmetry, report number XX, on March 7.
The review encompasses analysis of the literature showing that the development of synthetic approaches to Tapentadol, an agonist of the μ-opioid receptor and norepinephrine reuptake inhibitor, has followed four, partially overlapping, phases. The most advanced approaches, based on stereoselective syntheses, appeared only after 2010. The majority of the chemistry examples presented in this review come from patent applications and as such have not been subjected to rigorous peer review, but may serve well as an inspiration to organic chemists for solving analogous synthetic problems.
The authors of the publication include Piotr Graczyk (Selvita S.A.), Olga Zbrojkiewicz (Selvita S.A.) and Sven Nerdinger (Sandoz GmbH).
The article is available from Science Direct.