Selvita and Sandoz chemists published in Bioorganic & Medicinal Chemistry

Krakow, Poland – 08 May 2018 – Selvita and Sandoz researchers have recently jointly published an article: “A short synthesis of Dronedarone, which appeared in the Bioorganic & Medicinal Chemistry.

The publication presents a modification of the Nenitzescu reaction was used to obtain Dronedarone from quinonimine 20 and 1,3-diketone 14 (R = CH2CH2CH2NBu2) in a two-stage process in almost 55% overall yield. Our results represent a significant improvement over other state-of-the-art methods as no extra steps for the decoration of the benzofuran core are required.

The authors of the publication include Barbara Piotrkowska and Piotr Graczyk from Selvita S.A.; Sven Nerdinger and Erwin Schreiner from Sandoz GmbH; Lovro Selič from Lek Pharmaceutical.

 

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