To advance our clients’ SBDD programs, save time, and increase the probability of success, we have developed protocols for time- and cost-effective production, purification, and crystallization of the following proteins:

Uniprot no. Short name Protein name Origin
P00915 CA1 Carbonic anhydrase 1 H. sapiens
P00918 CA2 Carbonic anhydrase 2 H. sapiens
P0AEB2 dacA D-alanyl-D-alanine carboxypeptidase DacA E. coli
P08506 dacC D-alanyl-D-alanine carboxypeptidase DacC E. coli
P0A6J8 ddlA D-alanine–D-alanine ligase A E. coli
P49895 DIO1 Type I iodothyronine deiodinase H. sapiens
P03372 ESR1 Estrogen receptor H. sapiens
P11362 FGFR1 Fibroblast growth factor receptor 1 H. sapiens
P0AES4 gyrA DNA gyrase subunit A E. coli
P0AES6 gyrB DNA gyrase subunit B E. coli
P08238 HSP 90-beta Heat shock protein HSP 90-beta H. sapiens
P06213 IR Insulin receptor H. sapiens
P00338 LDHA L-lactate dehydrogenase A chain H. sapiens
P07195 LDHB L-lactate dehydrogenase B chain H. sapiens
Q14680 MELK Maternal embryonic leucine zipper kinase H. sapiens
P14598 NCF1 Neutrophil cytosol factor 1 H. sapiens
Q14995 Rev-erb-beta/NR1D2 Nuclear receptor subfamily 1 group D member 2 H. sapiens
P61586 RhoA Transforming protein RhoA H. sapiens
Q96EB6 Sirt1 NAD-dependent protein deacetylase sirtuin-1 H. sapiens
P04818 TS Thymidylate synthase H. sapiens
P12461 TS Thymidylate synthase C. albicans
P40337/Q15370/Q15369 VBC von Hippel-Lindau disease tumor suppressor/elongin-B/elongin-C H. sapiens
F8W4B7 zHDAC6 Histone deacetylase 6 D. rerio

Project RPMP.01.02.01-12-0460/17 “Development of structural analysis services of protein-ligand complexes in ‘fast track’ mode” was co-financed by the European Union from the European Regional Development Fund under the Regional Operational Programme for the Małopolska Region 2014-2020.