Selvita offers assays on primary cells and lung tissue focusing on myofibroblast activation, extracellular matrix production, tissue remodelling and macrophage polarisation.
The in vitro assays for evaluation of prospective anti-fibrotic drugs include:
We also offer ex vivo assays in tissue explants and precision-cut slices e.g.:
Assay read-outs:
In vivo models of fibrosis
Bleomycin-induced pulmonary fibrosis (mice)
Read-outs:
CCl4-induced liver fibrosis (mice)
Read-outs:
CDHFD-induced NASH and liver fibrosis (mice)
Read-outs:
Unilateral ureteral obstruction (UUO) model of renal fibrosis (mice)
Read-outs:
Folic acid-induced renal fibrosis (mice)
Read-outs:
For more information about our fibrosis models please contact us.