Poster presentations

This section includes poster presentations of executed research projects which were subsequently presented on scientific conferences.

The following poster presentations are authored both by Selvita scientists as well as our Partner’s scientists.

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Evaluation of semisynthetic high-fat diets in development of a 4-week mouse NASH model
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    Photomediated Synthesis of α,α-Difluoroalcohols
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      Repurposing of tetracycline antibiotics as new immuno-oncology agents
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        Identification and characterisation of a dual GLP-1/GLP-2 agonist peptide, HTL0030023 using structure based drug design
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          Photomediated Synthesis of α,α-Difluoroalcohols poster
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            LC/HRMS ORBITRAP Technique - Essential tool in drug development process
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              Cloning and Expression Platform for Production of Recombinant Proteins
              The poster describes the cost and time-effective Selvita platform for cloning and E. coli expression (which is only one of our platforms for expression).
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                A short synthesis of Dronedarone
                Selvita’s chemists are adept at designing enhanced approaches to target molecules and in this poster and paper illustrate how they collaborated on a synthesis of the atrial fibrillation drug Dronedrone which has been reworked to more than half the number of synthetic steps using efficient and environmentally friendly chemistry.
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                  A new competitive strategy for the industrial synthesis of drugs based on chiral amines via utilizing the waste isomer by flow chemistry
                  Selvita has an ongoing commitment to expand chemistry technology to facilitate efficient access to intermediates and final compounds. One such technique which has been developed at Selvita is the application of flow chemistry techniques in synthesis.   In the linked poster Selvita scientists have described a flow chemistry approach to recycle the “waste’ isomer product from a non-enantiospecific primary amine synthesis, offering a means to enhance the yield of desired isomer in synthesis of drugs such as Cinacalcet and Rivastigimine.
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                    Human precision-cut lung slices as a model for testing compounds against human rhinovirus
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                      Translation from mice and cells to humans: GM-CSF and IL-1β as biomarkers of anti-inflammatory activity of azithromycin
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                        Macrolide inspired macrocycles as a promising templates for challenging targets
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                          Precision-cut lung slices as an in vitro model for testing of novel therapeutic agents
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                            Expression of Wingless-related integration site-3α (Wnt-3α) and Olfactomedin4 (OLFM4) in pseudopyloric metaplasia of small intestine in patients with Crohn disease
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                              Lung goblet cell hyperplasia/metaplasia quantification in a murine model of respiratory syncytial virus induced pulmonary inflammation using digital image analysis
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                                Elafibranor effectively reduces development of CDAHFD-induced non-alcoholic steatohepatitis (NASH) and fibrosis in mice
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                                  Macrolide inspired macrocycles: design and biological evaluation
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