Scaling up key molecules can revolutionize the way you do chemistry for the project. For example, with one key intermediate you can increase the chemist’s productivity multi-fold, consequently boosting the whole decision making process. And if speed is not the only thing you need, we can provide:
- Synthesis of an advanced intermediate that will accelerate your process
- Optimization of reaction conditions
- Process development
- Large scale synthesis of an advanced intermediate
- Large scale synthesis of standards and building blocks
- Larger compound quantities for in vivo studies
- And any other request from milligram to multigram scale
The scale-up team is a group of well-educated and highly experienced organic chemists, medicinal chemists and chemical engineers that can offer solutions to your requirements in a quick and efficient manner.
Our non-GMP scale-up laboratory is equipped with:
- Several Double-jacketed glass reactors (1-50L)
- Hydrogenation autoclave (1-4 L)
- 10 L and 20 L rotary evaporators
- Mini-plant scale setup (6L jacketed reactor equipped with efficient stirrer, condenser and receivers) – ideally for reactions, work-up and crystallization
- Drying chamber and vacuum dryer
- Centrifuges (0.1 and 1 kg load)
- Dozen highly precise and powerful thermostats.
We are able to perform various reactions within a wide temperature range (from -78 °C to 200 °C) and under different pressures (small scale to 100 bar, large scale to 10 bar).
The scale-up laboratory is well supported by the internal discovery analytical services, structural analysis, as well as the solid state characterization capabilities.
The improvement of your synthetic route is our challenge – to maintain the product’s high quality, while making the route:
- Cheaper – increase yields, shorten the reaction time, improve work-up
- Greener – decrease waste generation, reduce number of solvents
- Safer – compliant to the highest safety and environmental regulations
- Reproducible and robust
By choosing Selvita’s scale-up team, you will ensure good protection of your intellectual property through our rigorous data integrity policy. After completing the task, each compound can be accompanied by either a detailed research report or Certificate of Analysis, both written in English.
Selected chemical transformations that we can perform on the scale: